Custom Peptides
Cayman Chemical ProstaglndIn B2 10mg
PGB2 is a non-enzymatic dehydration product resulting from the treatment of PGE2 or PGA2 with strong base. It has weak agonist activity on TP receptors and can increase pulmonary blood pressure in the rabbit at relatively high doses (5 UG/kg).{1301}
Cayman Chemical NorursodeoxycholIc AcId 10mg
A bile acid; is secreted in an unchanged form, as trihydroxy derivatives, or as sulfate or glucuronide conjugates; decreases serum levels of ALT and alkaline phosphatase, periductal fibrosis, and hepatic hydroxyproline content in an Mdr2-/- mouse model of sclerosing cholangitis at 0.5% w/w in the diet
Cayman Chemical ngIotensIn Ihumnratmo 10mg
A peptide; is converted to the vasoconstrictor angiotensin II by ACE; binds to angiotensin receptors in human myometrium membrane preparations (Kd = 11.2 nM); increases the renal vascular resistance in isolated rat kidney (EC50 = 10.5 nM); increases MAP and plasma AVP level in fetal ewes (5 μg/kg, i.c.v.)
Cayman Chemical DelavIrdInmesylate 10mg
A NNRTI; selectively inhibits HIV-1 reverse transcriptase over DNA polymerase α and δ in vitro (IC50s = 0.26, 440, and >550 μM, respectively); blocks replication of 25 primary HIV-1 isolates (mean ED50 = 0.066 μM); inhibits growth of L. infantum promastigotes (IC50 = 26.1 μM)
Cayman Chemical 1 2DIpalmItoyl3Oleoylrac 10mg
A triacylglycerol; has been found in Apiaceae seed oils, lard, tallow, as well as palm oil, olein, and stearin; has been used as a substrate to determine the regioselectivity and substrate specificity of lipases from Geotrichum species
Cayman Chemical CarIprazInhydrochlorIde 10mg
An atypical antipsychotic; binds to dopamine D2L, D2S, and D3, 5-HT1A, 5-HT2A, 5-HT2B, histamine H1, and σ1 receptors (Kis = 0.085-23.44 nM); an antagonist of dopamine D2 and D3 receptors (Kbs = 0.759 and 0.316 nM, respectively); a partial agonist at dopamine D2 and D3 receptors; stimulates inositol phosphate production in murine A9 cells expressing human D2L receptors (EC50 = 3.16 nM); inhibits forskolin-induced cAMP accumulation in CHO cells expressing human D3 receptors (EC50 = 2.63 nM); inhibits amphetamine-induced hyperactivity and the conditioned avoidance response in rats (ED50s = 0.12 and 0.84 mg/kg, respectively); inhibits scopolamine-induced learning deficits in a water labyrinth learning test in rats from 0.02-0.08 mg/kg
Cayman Chemical 13C64NItrophenylhydrazIn 10mg
An internal standard for the quantification of 4-nitrophenylhydrazine by GC- or LC-MS; a byproduct in the synthesis of 13C6-3-nitrophenylhydrazine
Cayman Chemical LIfItegrastsodIum salt 10mg
An inhibitor of the LFA-1/ICAM-1 interaction; binds to LFA-1 and blocks the adhesion of Jurkat T cells or HuT 78 cells to ICAM-1 (IC50s = 2.98 and 9 nM, respectively) and inhibits secretion of various cytokines from these cells; increases tear production in dogs with idiopathic keratoconjunctivitis sicca; topical application inhibits LFA-1-dependent neutrophil recruitment to the eye in mouse models of contact lens-associated corneal inflammation induced by corneal abrasion and tobramycin-killed bacteria
Cayman Chemical CGP 71683hydrochlorIde 10mg
An antagonist of NPY receptor Y5 (IC50 = 1.4 nM in a radioligand binding assay); selective for Y5 over Y1, Y2, and Y4 receptors (IC50s = 2,765, 7,187, and 5,637 nM, respectively); inhibits NPY-induced increases in BT-549 cell growth and MDA-MB-231 cell migration at 0.25 μM; inhibits increases in food intake induced by intracerebroventricular administration of NPY in rats at 10 mg/kg, i.p.
Cayman Chemical mthyl alnolnyl Fluorophos 10mg
An analog of MAFP, which has been widely studied as an inhibitor of phospholipases, FAAH, and as a CB receptor ligand; pharmacology of the α-linolenyl analog of MAFP has not been completely investigated
Cayman Chemical SynthetIc DIeugenol 10mg
A neolignan with antioxidative and antiprotozoal activities; inhibits TBARS formation and scavenges superoxide anions, but not hydroxyl radicals, in cell-free assays; has anti-trypanosomal activity against T. cruzi amastigotes and trypomastigotes (IC50s = 15.1 and 11.5 µM, respectively) but is cytotoxic to NCTC L-929 fibroblasts (CC50 = 58.2 µM); disrupts the integrity of the T. cruzi trypomastigote plasma membrane but does not induce ROS production in trypomastigotes or LPS-stimulated and unstimulated isolated mouse peritoneal macrophages
Cayman Chemical ZK 756326hydrochlorIde 10mg
A non-peptide agonist of CCR8; inhibits binding of CCL1 to human CCR8 (IC50 = 1.8 µM); stimulates extracellular acidification in cells expressing human and mouse CCR8 (EC50s = 254 nM and 2.6 µM, respectively); exhibits >28-fold selectivity for CCR8 over 26 other GPCRs; binds to the serotonergic receptors 5-HT1A, 5-HT2B, 5-HT2C, and 5-HT5A (IC50s = 5.4, 4.4, 34.8, and 16 µM, respectively); induces Gαi-mediated calcium mobilization, ERK phosphorylation, exhibits leukocyte chemotactic activity, and inhibits HIV fusion of cells expressing CD4 and CCR8
Cayman Chemical MBX-8025sodIum salt 10mg
A PPARδ agonist; >750- and >2,500-fold selective for PPARδ over PPARα and PPARγ; reduces increases in fasting blood glucose and serum insulin levels, and decreases insulin resistance in Alms1 mutant (foz/foz) mice fed an atherogenic diet as a model of diet-induced obesity, type 2 diabetes, and NASH at 10 mg/kg per day for eight weeks; decreases serum ALT, as well as serum and hepatic cholesterol and triglyceride, levels and reduces markers of NASH in the same model
Cayman Chemical 1MyrIstoyl3Butyrylracgly 10mg
A diacylglycerol containing myristic acid at the sn-1 position and butyric acid at the sn-3 position
Cayman Chemical ScutelareIn 10mg
A flavone; has antioxidant activity in a TRAP assay at 1 μg/ml; inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the SARS coronavirus helicase nsP13 (IC50s = 12 and 0.86 μM, respectively); decreases LPS-induced NO release and iNOS and TNF-α mRNA expression in RAW 264.7 macrophages at 50 μM; decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model at 0.5 μg/g